2016 Feb 23 - Aspirin-Exacerbated Respiratory Disease — New Prime Suspects
Tanya M. Laidlaw and Joshua A. Boyce,
N Engl J Med 2016; 374:484-488 February 4, 2016
NSAIDs that inhibit cyclooxygenase-1 can provoke severe asthma and rhinosinusitis with nasal polyps and eosinophil infiltration. Cysteinyl leukotriene generation by the leukotriene C4 synthase pathway may cause the bronchoconstriction, vascular leak, and mucous secretion.
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